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Selective Cox 1 Inhibitors. Diese Substanzen dürfen jedoch nicht als COX-1-selektive Inhibitoren bezeichnet wer-den da sie ja ihre AnalgesieAntiinflammation über die COX-2-Hemmung entfalten. There are two main types of COX enzymes. The main COX inhibitors are the non-steroidal anti-inflammatory drugs NSAIDs. Among them mofezolac is.
Some COX-1 drugs inhibit the enzyme transiently whereas others eg ASA permanently inhibit TXA2 production for the lifespan of the platelet. All these insights allowed the design of new highly selective COX-1 inhibitors to be tested into those disease models in which COX-1 is involved. COX Inhibitor Treatments. Thus three series of quinazoline derivatives were prepared and tested for their potential inhibitory activity toward COX-1 and COX. NSAIDs Salicylates Aspirin Diflunisal Salsalate Aspirin Diflunisal Salsalate Propionic acid derivatives Ibuprofen Ketoprofen Naproxen Oxaprozin Fenoprofen Ibuprofen Ketoprofen Naproxen Oxaprozin Fenoprofen Acetic Acid. Classification of COX 1 Inhibitors.
The classical COX inhibitors are not selective and inhibit all types of COX.
This review has also the scope to stimulate the development of novel drugs which activity is COX-1 mediated. Non-steroidal anti-inflammatory drugs NSAIDs are the competitive inhibitors of cyclooxygenase COX the enzyme which mediates the bioconversion of arachidonic acid to inflammatory prostaglandins PGs. COX-1 inhibitors such as acetylsalicylic acid ASA inactivate platelet COX-1 a pivotal enzyme in TXA2 and prostacyclin synthesis important for platelet secretion and aggregation. The main COX inhibitors are the non-steroidal anti-inflammatory drugs NSAIDs. NSAIDs Salicylates Aspirin Diflunisal Salsalate Aspirin Diflunisal Salsalate Propionic acid derivatives Ibuprofen Ketoprofen Naproxen Oxaprozin Fenoprofen Ibuprofen Ketoprofen Naproxen Oxaprozin Fenoprofen Acetic Acid. An increasing number of selective COX-1 inhibitors has been found such as TFAP ABEX-3TF FR122047 SC-560 P6 and mofezolac Figs.