16
Dec
Metabolic Pathway Of Vitamin D. 125-Dihydroxyvitamin D3 is metabolized to a C-23 carboxylic acid calcitroic acid but the pathway is unknown. Polymorphisms in vitamin D pathway genes are candidates for association with MS susceptibility. DHCR7 encodes the enzyme 7-dehydrocholesterol 7-DHC reductase which converts 7-DHC to cholesterol thereby removing the substrate from the synthetic pathway of vitamin. 125-Dihydroxyvitamin D 3 is metabolized to a C-23 carboxylic acid calcitroic acid but the pathway is unknown.
Photochemical synthesis of vitamin D3 cholecalciferol D3 occurs cutaneously where pro-vitamin D3 7-dehydrocholesterol is converted to pre-vitamin D3 pre-D3 in response to ultraviolet B sunlight exposure. Although 25-hydroxyvitamin D3 is metabolized to 24R25-dihydroxyvitamin D3 2526-dihydroxyvitamin D3 and 25-hydroxyvitamin D3-2623-lactone. Several recent studies show that DBP levels in the cerebrospinal fluid correlate with MS course being lower during relapses and higher in the secondary progressive phase. Vitamin D is transported in the blood by vitamin D binding protein DBP. PTH FGF23klotho and 125OH 2 D 3 play key roles in the regulation of optimal levels of 125OH 2 D 3. Which binds vitamin D and its metabolites in serum to the liver.
Only products of 125OH 2 D 3 are represented for the C23 lactone pathway.
The major natural source of the vitamin is synthesis of cholecalciferol in the lower. Vitamin D is transported in the blood by vitamin D binding protein DBP. We review here evidence supporting a role of DBP in MS. The metabolic pathway for vitamin D. Only products of 125OH 2 D 3 are represented for the C23 lactone pathway. The role of extrarenal 1alphaOHase in.